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Unexplained anemia: Particularly in a specific form (megaloblastic anemia) where the red blood cells are enlarged, a vitamin B12 deficiency is a common cause

All authors contributed to the article and approved the submitted version

al published the first Gene Review of Disorders of Intracellular Cobalamin Metabolism

If none of the above has failed along the way, B12 has reached its first destination safe and sound

As deficiency deepens, neurological symptoms can appear: tingling or numbness in the hands and feet, balance problems, a sore or "beefy" red tongue, memory changes, and mood shifts

Folates and S-adenosylmethionine for major depressive disorder